A bis-urea naphthalene macrocycle displaying two crystal structures with parallel ureas

Absorption Properties of a Porous Organic Crystalline Apohost Formed by a Self-Assembled Bis-Urea Macrocycle

Self-assembly of a bis-urea macrocycle into a columnar nanotube.

A bis-urea macrocycle 1 was synthesized and shown to form extended nanotubular columns by X-ray crystallography.

Double threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine–thymine mismatch

The macrocyclic bis-naphthalene macrocycle (2,7-BisNP), belonging to the cyclobisintercalator family of DNA ligands, recognizes T-T mismatch sites in duplex DNA with high affinity and selectivity, as evidenced by thermal denaturation experiments and NMR titrations. The binding of this macrocycle to an 11-mer DNA oligonucleotide containing a T-T mismatch was studied using NMR spectroscopy and NM...

Crystal structures of human SIRT3 displaying substrate-induced conformational changes.

SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat metabolic and neurological diseases. We report the first sets of crystal structures of human SIRT3, ...

1,4-Bis(chloro­meth­yl)naphthalene

In the title mol-ecule, C(12)H(10)Cl(2), the torsion angles C(r)-C(r)-C(m)-Cl around the C(m)-C(r) bonds have values of -104.1 (4) and -101.9 (4)°, where C(m) is a methylene and C(r) is a ring C atom. The mol-ecules related by translation along the b axis are arranged into stacks by π-π inter-actions between unsubstituted and substituted aromatic rings of the naphthalene ring system (centroid-c...